Beta adrenoreceptor subtype cross regulation in the human heart.
نویسندگان
چکیده
منابع مشابه
Beneficial effects of chronic pharmacological manipulation of beta-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy.
BACKGROUND Studies in isolated cardiac myocytes have demonstrated that signaling via specific beta1-adrenergic receptor subtypes (beta1ARs) promotes but that signaling via beta2ARs protects from cell death. We hypothesized that prolonged beta(2)AR stimulation or beta1AR blockade would each protect myocytes from death and thereby ameliorate cardiac remodeling in chronic heart failure. METHODS ...
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متن کاملSelective and non-selective beta-adrenoreceptor blockade in the human forearm.
1. The immediate effects of selective (Pl) and non-selective (pl + 2) Padrenoreceptor blockade on local blood flow and substrate exchange were studied in young male subjects at rest and during dynamic forearm exercise. After a control period of rest, exercise and recovery, atenolol (PI), propranolol (/31+2) or placebo was infused into the right brachial artery during a second period of rest, ex...
متن کاملRegional pre- and postsynaptic sympathetic system in the failing human heart--regulation of beta ARK-1.
OBJECTIVES Regional presynaptic sympathetic innervation varies considerably in the cardiomyopathic human heart, as shown in previous studies in vivo and in vitro. The goal of the present study was to correlate markers of presynaptic sympathetic innervation with local measurement of the postsynaptic beta-adrenergic system in failing human hearts. METHODS AND RESULTS In nine left ventricular re...
متن کاملBeta-adrenoreceptor blocking drugs and thyroid hormones in hyperthyroid subjects.
Serum thyroid hormone concentrations were measured before and during 10 days' treatment with atenolol (200 mg/day), acebutolol (400 mg/day), oxprenolol (160 mg/day) and propranolol (160 mg/day) in 24 hyperthyroid patients. During propranolol treatment serum triiodothyronine (T3) concentrations fell significantly (P less than 0.05) but there was no change in thyroid hormone concentrations in the...
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ژورنال
عنوان ژورنال: Heart
سال: 1993
ISSN: 1355-6037
DOI: 10.1136/hrt.69.4.332